Stem cell therapy could help reverse premature ovarian insufficiency

According to preliminary results from the ongoing ROSE clinical trial, autologous human bone marrow mesenchymal stem cells were able to aid in the reversal of hypo-estrogenemia, subsequently followed by the resumption of regular menstruation, reported Propser Igboeli, MD, of Augusta University in Georgia and colleagues, at ENDO 2018.

Premature ovarian insufficieny (POI) affects around 1% of reproductive age women under age 40, and often has an unknown cause in the majority of women, but could be a genetic basis for resistant ovary syndrome.

The authors tested stem cell therapy in preclinical animal models, and found that human mesenchymal reversed POI-associated morbidity and infertility.

The stem cells were the transplanted into the right ovary laparoscopically, while the left ovary was injected with saline to serve as a control. Due to inactivity, the two patients’ ovaries were roughly a third of the size of normally functioning ovaries.

The next phase of the clinical trial is scheduled to enroll 33 participants. Al-Hendy also said this type of treatment may have application in other reproductive disorders including polycystic ovary syndrome (PCOS) and recurrent pregnancy loss.