According to preliminary results from the ongoing ROSE clinical trial, autologous human bone marrow mesenchymal stem cells were able to aid in the reversal of hypo-estrogenemia, subsequently followed by the resumption of regular menstruation, reported Propser Igboeli, MD, of Augusta University in Georgia and colleagues, at ENDO 2018.
Premature ovarian insufficieny (POI) affects around 1% of reproductive age women under age 40, and often has an unknown cause in the majority of women, but could be a genetic basis for resistant ovary syndrome.
The stem cells were the transplanted into the right ovary laparoscopically, while the left ovary was injected with saline to serve as a control. Due to inactivity, the two patients’ ovaries were roughly a third of the size of normally functioning ovaries.
The next phase of the clinical trial is scheduled to enroll 33 participants. Al-Hendy also said this type of treatment may have application in other reproductive disorders including polycystic ovary syndrome (PCOS) and recurrent pregnancy loss.
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