According to preliminary results from the ongoing ROSE clinical trial, autologous human bone marrow mesenchymal stem cells were able to aid in the reversal of hypo-estrogenemia, subsequently followed by the resumption of regular menstruation, reported Propser Igboeli, MD, of Augusta University in Georgia and colleagues, at ENDO 2018.

Premature ovarian insufficieny (POI) affects around 1% of reproductive age women under age 40, and often has an unknown cause in the majority of women, but could be a genetic basis for resistant ovary syndrome.

The authors tested stem cell therapy in preclinical animal models, and found that human mesenchymal reversed POI-associated morbidity and infertility.

The stem cells were the transplanted into the right ovary laparoscopically, while the left ovary was injected with saline to serve as a control. Due to inactivity, the two patients’ ovaries were roughly a third of the size of normally functioning ovaries.

The next phase of the clinical trial is scheduled to enroll 33 participants. Al-Hendy also said this type of treatment may have application in other reproductive disorders including polycystic ovary syndrome (PCOS) and recurrent pregnancy loss.