Severely ill COVID patients who received two intravenous doses of stem cells three days apart were much more likely to survive and recover quickly, researchers found. “The results are quite spectacular,” said senior researcher Dr. Camillo Ricordi, director of the Diabetes Research Institute and Cell Transplant Center at the University of Miami Miller School of […]

Cord blood stem cells are used in two broad areas of medicine. Since the first cord blood transplant for Matt Farrow in 1988, cord blood has been used in over 40 thousand transplants worldwide for 80+ diseases.   The use of cord blood for transplants is considered a “homologous” application of the stem cells, because […]

Diabetes mellitus (DM) is a terribly growing epidemic, currently affecting about 463 million people worldwide, with expected rise to 700 million by the year 2045. It is the most prevalent metabolic disease, in which insulin secreting β cells are damaged to various extents. Different etiologies and interfering factors exist for each of type 1 and […]

A new study led by UC Davis MIND Institute researchers found a distinct DNA methylation signature in the cord blood of newborns who were eventually diagnosed with autism spectrum disorder (ASD). This signature mark spanned DNA regions and genes linked to early fetal neurodevelopment. The findings may hold clues for early diagnosis and intervention. The […]

Amyotrophic lateral sclerosis (ALS) is still incurable. Although different therapies can affect the health and survival of patients. Our aim is to evaluate the effect of umbilical mesenchymal stem cells administrated intrathecally to patients with amyotrophic lateral sclerosis on disability development and survival. This case-control study involved 67 patients treated with Wharton’s jelly mesenchymal stem […]

In the attempt to find a possible cure for Alzheimer’s disease (AD), mesenchymal stem cells (MSCs) and their derived extracellular vesicles (EVs) are being investigated for therapeutic purposes thanks to their protective and anti‐inflammatory properties. The results from this study show that MSC‐EVs operate in dampening inflammation (that favors and accelerates the pathogenic process in […]

Studies suggest that the use of mesenchymal stem cells collected from umbilical cord blood and tissue are a safe and effective way to alleviate symptoms of coronavirus and promote fast recovery. Recently, mesenchymal stem cells (MSCs) harvested from umbilical cord blood have attracted significant attention in clinical trials for COVID-19 due to their immunomodulatory and […]

A team of researchers at the Washington University School of Medicine in St. Louis have converted human stem cells into insulin-producing cells, controlling the blood sugar levels of laboratory mice. Within just nine months, the mice had been cured of diabetes, hinting that the procedure may be used in humans to cure diabetes. Published in […]

Last March, scientists announced that Mr. Castillejo, then identified only as the “London Patient,” had been cured of H.I.V. after receiving a bone-marrow transplant for his lymphoma. The donor carried a mutation that impeded the ability of H.I.V. to enter cells, so the transplant essentially replaced Mr. Castillejo’s immune system with one resistant to the virus. The […]

Preterm birth and its complications are the leading cause of neonatal death. The main underlying pathological mechanisms for preterm complications are disruption of the normal maturation processes within the target tissues, interrupted by premature birth. Cord blood, as a new and convenient source of stem cells, may provide new, promising options for preventing preterm complications. […]

Benefits of cord blood transplantation include low rates of relapse and chronic graft-versus-host disease (GVHD). However, the use of cord blood is rapidly declining because of the high incidence of infections, severe acute GVHD, and transplant-related mortality. UM171, a haematopoietic stem cell self-renewal agonist, has been shown to expand cord blood stem cells and enhance […]

Intravenous infusion of banked autologous and sibling umbilicalcord blood (CB) is being studied in children with acquired neu-rological conditions and has demonstrated safety and feasibilityin phase I/II studies. To provide access to this investigationalprocedure while efficacy trials are conducted, an expandedaccess program (EAP) was developed. More than 1,400 children have enrolled in the screening protocol […]